2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-10119S
    Vorapaxar-d5 98%
    Vorapaxar-d5 is deuterated labeled Vorapaxar (HY-10119). Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.
    Vorapaxar-d5
  • HY-101235
    ICI 185282 106393-80-0 98%
    ICI 185282 is a potent, selective, orally active thromboxane A2 (TXA₂) receptor antagonist. ICI 185282 causes dose-dependent inhibition of U-46619 (HY-108566)-induced platelet aggregation ex-vivo in guinea-pig. ICI 185,282 inhibits bronchospasm induced by U-46619, PGD2 (HY-101988), PGF2α (HY-12956), arachidonic acid (HY-109590), LTD4 and PAF (HY-108635) in vivo. ICI 185282 can be used for bronchial asthma research.
    ICI 185282
  • HY-101304
    S-Isopropylisothiourea hydrobromide 4269-97-0 98.0%
    S-Isopropylisothiourea hydrobromide (S-isopropyl ITU; IPTU) is a blood-brain barrier (BBB) penetrant NOS inhibitor with IC50 values of 0.66, 0.75 and 0.29 μM against mouse spinal cord, cerebellar, bovine aortic and porcine endothelial cell NOS. S-Isopropylisothiourea exhibits a significant blood pressure-raising effect without damaging the perfusion of vital organs and can also inhibit the late-phase pain response induced by formalin. S-Isopropylisothiourea hydrobromide is used in the researchs for hemorrhagic shock and pain response based on NOS.
    S-Isopropylisothiourea hydrobromide
  • HY-101345
    AH 11110A 179388-65-9 98%
    AH 11110A is an α1B-adrenoceptor antagonist, but it can't effectively distinguish between the different subtypes of alpha(1) adrenoceptors (A, B, and D), nor can it clearly differentiate between alpha(1) and alpha(2) adrenoceptors.
    AH 11110A
  • HY-101355
    CGP 20712 137888-49-4 98%
    CGP 20712 is a highly selective β1-adrenoceptor antagonist (Ki=0.3 nmol/L). CGP 20712’s primary mechanism of action is through competitively binding to β1-receptors, thereby blocking the positive chronotropic effects of adrenaline and noradrenaline.
    CGP 20712
  • HY-101393
    CGP 12177 81047-99-6 98%
    CGP 12177 ((±)-CGP 12177) is a β-Adrenergic receptor (β-AR) ligand. CGP 12177 is a β3-AR (Ki = 88 nM) agonist with β1/β2-AR (Ki = 0.9 nM for β1; Ki = 4 nM for β2) antagonist action. CGP 12177 exhibits partial agonist properties for α1-AR in rat pulmonary artery. CGP 12177 regulates the expression of ucp and leptin genes in NMRI mice adipose tissues. CGP 12177 can be used for cardiovascular and metabolic disease research.
    CGP 12177
  • HY-101433
    N-Acetylprocainamide hydrochloride 34118-92-8 99.83%
    N-Acetylprocainamide (Acecainide) hydrochloride is a class III antiarrhythmic, which blocks K+ channels. N-Acetylprocainamide hydrochloride exerts inhibitory effects on the maximum following frequency (MFF) of isolated rabbit atria. N-Acetylprocainamide hydrochloride can be used for the study of arrhythmias.
    N-Acetylprocainamide hydrochloride
  • HY-101436
    Sematilide 101526-83-4 98%
    Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent.
    Sematilide
  • HY-101542
    Milfasartan 148564-47-0 98%
    Milfasartan (LR-B/081) is a selective angiotensin receptor AT1 antagonist with antihypertensive activity.
    Milfasartan
  • HY-101599
    IP-66 58013-09-5 98%
    IP-66 is a potent postsynaptic alpha-receptor antagonist. IP-66 can be used for the research of cardiovascular disease, such as hypertension.
    IP-66
  • HY-101602
    Aligeron 70713-45-0 98%
    Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.
    Aligeron
  • HY-101606
    Etersalate 62992-61-4 98%
    Etersalate inhibits platelet function and decreases thromboxane A2 (TXA2) levels.
    Etersalate
  • HY-101607
    KT-362 105394-80-7 98%
    KT-362 is an intracellular calcium antagonist. KT-362 can inhibit NE-induced contractions and IP accumulation in vivo experiments.
    KT-362
  • HY-101646
    Saviprazole 121617-11-6
    Saviprazole is a Proton Pump inhibitor. Saviprazole can be used in research related to gastrointestinal diseases, such as gastric ulcers and acid reflux.
    Saviprazole
  • HY-101649
    Imiglitazar 250601-04-8 98%
    Imiglitazar (TAK559) is a potent and dual human PPARα and PPARγ1 agonist with EC50 values of 67 and 31 nM.
    Imiglitazar
  • HY-101654
    Rocepafant 132579-32-9 98%
    Rocepafant (BN 50730) is a specific platelet activating factor (PAF) antagonist. Rocepafant can be used in rheumatoid arthritis and nervous system research.
    Rocepafant
  • HY-101675
    Setipafant 132418-35-0 98%
    Setipafant is a platelet-activating factor (PAF) antagonist.
    Setipafant
  • HY-101707
    UK51656 88150-59-8 98%
    UK51656 is a calcium antagonist with IC50 of 4 nM.
    UK51656
  • HY-101740
    SQ-31765 138383-07-0 98%
    SQ-31765 is a benzazepine calcium channel blocker.
    SQ-31765
  • HY-101752
    (±)-Befunolol 39552-01-7 98%
    (±)-Befunolol is a β-adrenoceptor blocking agent.
    (±)-Befunolol
Cat. No. Product Name / Synonyms Application Reactivity